منابع مشابه
How I treat How I treat acquired aplastic anemia
Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive biologics and drugs, and supportive care. However, management of SAA patients remains challenging, both acutely in addressing the immediate consequences of pancytopenia and in the long term because of the disease’s natural history...
متن کاملHow I treat acquired aplastic anemia.
Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive biologics and drugs, and supportive care. However, management of SAA patients remains challenging, both acutely in addressing the immediate consequences of pancytopenia and in the long term because of the disease's natural history...
متن کاملHow I treat acquired aplastic anemia
AcquiredSAAis regardedas the resultof an immune-mediateddestruction of hematopoietic cells, at least in a proportion of patients. The emergence of late clonal disorders in10%to20%ofpatients after immunosuppressive therapy (IST) raises the questions of whether some patients with SAA actually have a premalignant disease and whether IST is just postponing the inevitable. Support for this view has ...
متن کاملHow I treat How I treat Diamond-Blackfan anemia
Diamond-Blackfan anemia (DBA) is characterized by red cell failure, the presence of congenital anomalies, and cancer predisposition. In addition to being an inherited bone marrow failure syndrome, DBA is also categorized as a ribosomopathy as, in more than 50% of cases, the syndrome appears to result from haploinsufficiency of either a small or large subunit-associated ribosomal protein. Noneth...
متن کاملAcquired aplastic anemia.
In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes. The aberrant immune response may be triggered by environmental exposures, such as to chemicals and drugs or viral infections and, perhaps, endo...
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ژورنال
عنوان ژورنال: Blood
سال: 2017
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2016-08-693481